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ʥꤢդФŤʤ뤷ޤȸ礤 Ȥʤ

2018ǯ04

˦䥿ѥʳʪˤŤоǤ礦ͻΩؤιⶶȶٻعȤϡȤä¸Ǿ´Υϥӥơȿθ䲽ʪ֥ɥͥԥޥ쥢ȡפͿȤ߹碌뤳ȤǡǾзȤۤƱˤޤDz뤳ȤǧǾ´ȯɸ1٤δ40оݤ˼ϤޤʤٻعȤٻΥեۡǥ󥰥Υ롼״ȤǤꡢƱҤۡǥ󥰥 л񤹤ȤǤٻؤʪedonerpic maleateϡ¤̤˺ΤǤϤʤǤ礦

2018ǯ44
ΩˡͲͻΩ
ٻعȳ

ͻΩ ؽѱط ⶶȶθ楰롼פٻΥե॰롼פٻعȳҡʰʲٻءˤϡȵ縦ꡢס򹯡ܸȤζƱˤꡢǾ´Υϥӥơ̤礭¥ʤ뿷θ䲽ʪꤷޤٻؤϾǧ˸Ǿ´βϥӥơԤäƤ봵ԤоݤȤ»ܤޤ
̤Υݥ
ٻؤʪedonerpic maleate*1Ǿ»εǽΥᥫ˥ǤǾβ夵뤳Ȥ餫ˤ
Ǿ»edonerpic maleateͿǾβ夷ϥӥơˤ뱿ưǽ̤뤳Ȥ򡢤ûࡢĹΥǥǼ

طʤȷа
Ǿ´ܤǯ30͡Ǥ1,700ͤȯɤƤȸ졢ФнƤԤμ礭㲼ޤǾ´βˤ뱿ưǽβŪȤŤϡƻʥȥ졼˥󥰤ˤϥӥơ󤬼ΤȤʤäƤޤθ̤ϸŪǤꡢŪʼˡ˾ޤƤޤ
αưǽΥᥫ˥ˤϡϥӥơγλɷ˱ǾѲǾβˤͿƤ뤳ȤΤƤޤǾβȤк˦ξãôʥץ*2ǤϡãʪФ줿ꡢ줿ꤹȤäѲޤ
Τˤ뵭ؽȤäŪѲȼäƥʥץȤãʪǤ륰륿ߥμΤΤҤȤĤǤAMPA*3ʥץä뤳ȤͻΩؤιⶶȶθ椫餫ˤƤꡢAMPAΤΥʥץܹԤǾβΥᥫ˥ΤҤȤĤǤ뤳ȤǧƤޤʻʸˡ


ܸ楰롼פϡ륹ѤƳˡ*4ŵŪˡ*5Ѥedonerpic maleateλɷ¸ŪAMPAΤΥʥץܹԤ¥ʤ뤳ȡǾβ夵뤳ȡˤޥ¸ǼޤޤˤܲʪɸŪCRMP2*6ȤѥǤ뤳Ȥ餫ˤޤǾβ»ǾǤͶƳǤСϥӥơŤθ̤¥ʤǤȹͤûࡢĹǾ»ǥѤڤԤޤ

ޤޥǾ»ǥαưǽɾˡۤǾ»edonerpic maleateͿȥϥӥơʻѤ뤳Ȥˤꡢưǽ뤳Ȥ餫ˤޤʿ1ˡ
Ǿ´Υϥӥơedonerpic1
ˡҥȤΤ褦˻ؤǤΤĤޤưɾǤ륫˥ѤơǾзedonerpic maleateͿȥϥӥơʻѤ뤳Ȥˤꡢؤ̩ʱưǤ뤳Ȥ餫ˤޤʿ2ˡؤǤΤĤޤưϥϥӥơŤǤ񤷤ȸƤޤ
Ǿ´Υϥӥơedonerpic2
θǼ줿ɷ¸ŪǾβѤ˴ŤǾ»αưǽ¥ʸ̤顢Ǿ´βˤϥӥơŸ¥ȤƤedonerpic maleateͭޤ

Ÿ
ǾβˤϥӥơŸ̤¥ʤ뿷򡢰᤯Ǿ´˶줷Ǥ봵ԤϤ뤳ȤܻؤޤٻؤϡǾ´βϥӥơԤäƤ봵ԤоݤȤ(ե)Ԥξɾɾɸ˲äҴŪɾɸѤ뤳Ȥǡedonerpic maleate׾ŪͭڤӰǧޤ

Ѹ
*1 edonerpic maleate ٻΥե॰롼פٻؤʪĥϥޡǧξɴԤоݤȤʳȯT-817MAˤ»ǤꡢͤǤǦǧƤޤ

*2 ʥץ к˦ƱΤĤʤк˦֤ξã濴ô¤Ρк˦ȡοк˦ΥʥץüФ줿ãʪ̤οк˦ΥʥץˤΤ˷礹뤳ȤǾޤ

*3 AMPAΡ Ǿ濴ŪôäƤãʪǤ륰륿ߥμΤΤҤȤĤǡʥץ˥ͥƤޤ륿ߥAMPAΤ˷礹ȡ˦˥ήʥץ뤿ᡢʥץAMPAΤοȥʥץޤʥץϵؽϤȤǾѲ濴Ūᥫ˥Ǥ뤳ȤΤƤޤ

*4 Ƴˡ ưʪ˰ҤƳȯˡθǤϡ륹ѤAMPAΤεǽ륿ѥΰҤʤɤޥǾȯ뤳Ȥˤꡢ»εǽAMPAΤפĤȤʤɤޤ

*5 ŵŪˡ к˦ȯŵ¬ꤹ뤳Ȥˤꡢк˦ξãɾˡ¸Ѥ뤳ȤˤꡢAMPAΤðŪŵȤ館뤳ȤǤޤ

*6 CRMP2(Collapsin-Response-Mediator-Protein2) мοĹ˳ʬҡǶθ椫ǾβˤؤäƤ뤳ȤƤޤ

Ǻʸ
CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage
Hiroki Abe, Susumu Jitsuki, Waki Nakajima, Yumi Murata, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya Takahashi

ܸϡʳػScience٤˷Ǻܤޤƹ452աܻ463ե饤

ܸϡʸʳؾʡ֥Υ١󥷥ƥ üͻΰ襤Υ١ϽеץסΩ泫ȯˡܰŸ泫ȯAMEDˡǾʳظάʥץͻǾˡסֳ׿ŪѤˤǾǽͥåȥƲץȡפʤɤνˤԤޤ

ʸ
Experience strengthening transmission by driving AMPA receptors into synapses
Takahashi et al. Science. 2003 Mar 7;299(5612):1585-8

Contextual learning requires synaptic AMPA receptor delivery in the hippocampus
Mitsushima et al. PNAS July 26, 2011. 108 (30) 12503-12508

A cholinergic trigger drives learning-induced plasticity at hippocampal synapses
Mitsushima et al. Nature Communications, volume 4, Article number: 2760 (2013)

Optical inactivation of synaptic AMPA receptors erases fear memory
Takemoto et al. Nature Biotechnology, volume 35, pages 38?47 (2017)

ȡCRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damageScience 06 Apr 2018




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2ϰ˱ɤäȤƤο
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3кѤȼҲȯŸΤο
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4ʬ礦
ʬ礦ȤڤˤĤƤȻפޤ
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ϴл㪤¿夬߹ߤ䤹ȬϼǤϡߤäϲȤʤޤϲϡ̤ˤǴڤؤξ䤹Ȥ顤ɸ1,100᡼ȥˤ¿ͯ夬ޤͯϤΤΡ겼ϤǤ礭ʲʤ夬­ѿͯʤƤϤʤޤǤơθ¤줿ᤰ꽸ƱΤ褤䤨ޤǤޤ籫ߤȡֲФפȤ뻳줬ˤȯѿϩ򲡤ήޤμ̿ϡ1943ǯβФˤäơ鲡ήƤ6᡼ȥεФǤꡤﳲ뤿ʸޤƤޤʼ̿11ˡҡ̿11
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6ưȿҳ
̤ϵ̯ǮХ󥹤͡˱ɤݻƤ뤳ȤˡϤ⤦դΤȤȻפޤʤ顤ΥХ󥹤ϸ߶ƤޤǤ礦ϡϵβȲȵưǤ
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ǯ7ˤϹϢϥ٥եHLPFˤǿνԤޤ8եबݼҲľ̤פʡơäŪ˸ơ򿼤ᡤư򵯤Ƥäˤʤ뤳ȤԤƤޤ

8
ǸˡδĴֱοδ˾ɽơȻפޤ21ϿǤȸƤޤθդĿʤߡ21Ͽˤ˱ɡʿ¤ƹʡǤäȸο͡˸ƤФ뤳ȤȤʤ褦äƤޤ³⶯ؿäƸäƤȻפޤ

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